117) A maresin 1/RORa/12-lipoxygenase
autoregulatory circuit prevents inalammation and progression of nonalcoholic
steatohepatitis, YH Han, KO Shin, DB Khadka, HJ Kim, YM Lee, WJ Cho,
JY Cha, BJ Lee, MO Lee, J. Clin. Invest., (2019), 130, 124219.
116) Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines
as novel topoisomerase I catalytic inhibitors, Daulat Bikram Khadka, Seojeong
Park, Yifeng Jin, Jinhe Han, Yongjoo Kwon, Won-Jea Cho, Eur. J. Med. Chem.,
(2018), 143, 200-215.
115) Piperidylmethyloxychalcone improves immunemediated acute liver failure
via inhibiting TAK1 activity, Sun Hong Park1, Jeong-Ah Kwak, Sang-Hun Jung,
Byeongwoo Ahn, Won-Jea Cho,
Cheong-Yong Yun,Chang Seon Na, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han
and Youngsoo Kim, Exp.
Mol. Med., (2017), 49, e392.
114) Berberine
bioisostere Q8 compound stimulates osteoblast differentiation and function
in vitro, Younho Han, Yifeng Jin, Sung Ho Lee, Daulat Bikram Khadka, Won-Jea Cho (co-corresponding),
Kwang Youl Lee, Pharmacol.
Res., (2017), 119, 463-475.
113) Caffeic Acid Cyclohexylamide
Rescues Lethal Inflammation in Septic Mice through Inhibition of IKB Kinase
in Innate Immune Process, Jun Hyeon Choi, Sun Hong Park, Jae-Kyung Jung,
Won-Jea Cho, Byeongwoo Ahn,
Cheong-Yong Yun, Yong Pyo Choi, Jong Hun Yeo, Heesoon Lee, Jin Tae Hong,
Sang-Bae Han & Youngsoo Kim, Scientic Report,
(2017) 7, 41180.
112) 6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl)nicotinamide-26
(DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation
of androgen receptor signaling in human prostate cancer cells, Choi HE, Shin
JS, Leem DG, Kim SD, Cho WJ,
Lee KT, Chem Biol Interact,
(2016), 260, 196-207.
111) Discovery of Isoquinolinoquinazolinones as a Novel Class of Potent
PPARgamma Antagonists with Anti-adipogenic Effects, Yifeng
Jin, Younho Han, Daulat Bikram Khadka, Chao Zhao, Kwang Youl Lee & Won-Jea Cho, Scientic Report, (2016)
6, 34661.
110) The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective
Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3, Sun-Mi Lee, Kyoung
Bin Yoon, Hyo Jeong Lee, Jiwon Kim, You Kyoung Chung, Won-Jea Cho,
Chisato Mukai, Sun Choi, Keon Wook Kang, Sun-Young Han, Hyojin Ko, Yong-Chul
Kim, Bioorg. Med. Chem., (2016),
24, 5036-5046.
109) Synthesis and Anticancer Activity of 2-Aryl-6-diethylaminoquinazolinone
Derivatives, Thanh Nguyen Le, Daulat Bilram Khadka, Giap Huu Tran, Dung Anh
Nguyen, Yifeng Jin, Hue Thi My Van, Van Hung Nguyen and Won-Jea Cho, Letters in Drug Design &
Discovery, (2016), 13, 684-690.
108) Insight into the Structural Features Essential for JAK2 Inhibition
and Selectivity, Zhao Chao, Khadka Bikram Daulat, Won-Jea Cho, Curr. Med. Chem.,
(2016), 23 (13), 1331-1355.
107) Design
and synthesis of novel androgen receptor antagonists via molecular modeling.
Zhao Chao, Choi You Hee, Daulat Bikram Khadka, Yifeng Jin, Kwang-Youl Lee,
Won-Jea Cho, Bioorg. Med. Chem., (2016),
24, 789-801.
106) Pharmacological effects of berberine and its derivatives: a patent
update, Yifeng Jin, Daulat B. Khadka, Won-Jea Cho, Expert Opin. Ther. Pat.,
(2016), 26 (2), 229-243.
105) Structure-Based
Discovery of Novel Cyclophilin A Inhibitors for the Treatment of Hepatitis
C Virus Infections, Suhui Yang, Jyothi K.R., Sangbin Lim, Tae Gyu Choi, Jin-Hwan
Kim, Salima Akter, Miran Jang, Hung-Jong Ahn, Hee-Young Kim, Marc P. Windisch,
Daulat B. Khadka, Chao Zhao, Yifeng Jin, Insug Kang, Joohun Ha, Bung-Chul
Oh, Meehyein Kim, Sung Soo Kim, Won-Jea Cho, J. Med. Chem., (2015),
58 (24), 9546-9561.
104) Substitued 2-arylquinazolinones: Design, synthesis, and evaluation
of cytotoxicity and inhibition of topoisomerases, Daulat B. Khadka, H. G.
Tran, S. Shin, T. M. H. Nguyen, H. C. Thi, C. Zhao, Y. Jin, H. T. M. Van,
V. M. Chau, Y. Kwon, T. N. Le and W.-J. Cho, Eur. J. Med. Chem.,(2015),
103, 69-79.
103) cAMP-dependent activation of protein kinase A as a therapeutic target
of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide, H.
Shin, S. D. Hong, E. Roh, S.-H. Jung, W.-J. Cho, S. H. Park, D. Y. Yoon,
S. M. Ko, B. Y. Hwang, J. T. Hong, T.-Y. Heo, S.-B. Han and Y. Kim, Br. J. Pharmacol.,
(2015), 172, 3434-3445.
102) Computer-aided discovery of aminopyridines as novel JAK2 inhibitors,
C. Zhao, S. H. Yang, D. B. Khadka, Y. Jin, K.-T. Lee, W.-J. Cho, Bioorg. Med. Chem., (2015),
23, 985-995.
101) Modification
of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their
cytotoxicity and topoisomerase inhibition, D. B. Khadka, H. Woo, S. H. Yang,
C. Zhao, Y. Jin, T. N. Le, Y. Kwon, W.-J. Cho, Eur. J. Med. Chem.,
(2015), 92, 583-607.
100) Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines
as topoisomerases inhibitors, H. T. M. Van, H. M. Jeong, D. B. Khadka, S.
H. Yang, C. Zhao, Y. Jin, K. Y. Lee. Y. Kwon, W.-J. Cho, Eur. J. Med. Chem.,
(2014), 82, 181-194.
99) Design
and Evaluation of w-Hydroxy Fattty Acids Containing a-GalCer Analogs for CD1d-Mediated
NKT Cell Activation, C. Lim, J. H. Kim, D. J. Baek, J.-Y. Lee, M. Cho, Y.-S.
Lee, C.-Y. Kang, D. H. Chung, W.-J.
Cho, and S. Kim, ACS Med. Chem. Lett.,
(2014), 5, 331-335.
98) Synthesis of novel 5-oxaprotoberberines as bioisosteres of protoberberines,
Y. Jin, D. B. Khadka, S. H. Yang, C. Zhao, W.-J. Cho, Tetrahedron Lett.,
(2014), 55, 1366-1369.
97) Scoparone Exerts Anti-Tumor Activity
against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity, J.-K.
Kim, J.-Y. Kim, H.-J. Kim, K.-G. Park, R.A. Harris, W.-J. Cho, J.-T. Lee, I.K. Lee,
Plos One, (2013),
8 (11), e80391.
96) Identification of daidzein as a ligand of retinoic acid receptor that
suppresses expression of matrix metalloproteinase-9 in HaCaT cells, H.-J.
Oh, Y-G Kang, T.-Y. Na, H.-J. Kim, J. S. Park, W.-J. Cho, and M.-O. Lee, Mol. Cell. Endocrinol.,
(2013), 376, 107-113.
95) (6,7-Dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine (CWJ-082) induces
mitotic arrest and apoptotic cell death through the activation of spindle
assembly checkpoint in human cervical cancer cells, KS Chung, HE Choi, JS
Shin, YW Cho, JH Choi, WJ Cho,
KT Lee, Carcinogenesis,
(2013), 34 (8), 1852-1860.
94) SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor
Antagonists for Prostate Cancer, Su-Hui Yang, Chin-Hee Song, Hue Thi My Van,
Eunsook Park, Daulat Bikram Khadka, Eun-Yeung Gong, Keesook Lee, and Won-Jea Cho, J. Med. Chem., (2013),
56 (8), 3414-3418.
93) Topoisomerase Inhibitors as Anticancer Agents: A Patent Update, Daulat Bikram Khadka and Won-Jea Cho, Expert Opin. Ther. Pat.,(2013),
23 (8), 1033-1056.
92) Hydroquinone regulates hemeoxygenase-1expression via modulation of
Src kinase activity through thiolation of cysteine residues. Se Eun Byeon,
TaoYu, Yanyan Yang, Yong Gyu Lee, Ji Hye Kim,Jueun Oh, Hye Yoon Jeong, Suntaek
Hong, Byong Chul Yoo,Won-Jea Cho,
Sungyoul Hong, Jae Youl Cho, Free Radic. Biol. Med.,
(2013),57, 105-118.
91) N-Methylthioureas as New Agonists
of Retinoic Acid Receptor-Related Orphan Receptor, Yohan Park, Suckchang Hong,
Myungmo Lee, Hyojun Jung, Won-Jea
Cho, Eun-Jin Kim, Ho-Young Son, Mi-Ock Lee, and Hyeung-geun Park,
Arch. Pharm. Res.,
(2012), 35 (8), 1393-1401.
90) Structure-Based Virtual Screening and Identification of
a Novel AR Antagonist,Chin-Hee Song,
Su Hui Yang, Eunsook Park, Suk Hee
Cho, Eun-Yeung Gong, Daulat Bikram Khadka, Won-Jea Cho (co corresponding)
,and Keesook Lee, J. Biol. Chem., (2012),
287 (36), 30769-30780.
89) Orphan nuclear receptor ERRγ is a key regulator of hepatic gluconeogenesis,
Don-Kyu Kim, Dongryeol Ryu, Minseob Koh, Min-Woo Lee, Donghyun Lim, Min-Jung
Kim, Yong-Hoon Kim, Won-Jea Cho,
Chul-Ho Lee, Seung Bum Park, Seung-Hoi Koo & Hueng-Sik Choi1, J. Biol. Chem., (2012),
287, 21628-21639.
88 ) Retinoic Acid Receptor–Related Orphan Receptor a–Induced Activation of Adenosine
Monophosphate–Activated
Protein Kinase Results
in Attenuation of Hepatic Steatosis Eun-Jin Kim, Young-Sil Yoon, Suckchang
Hong, Ho-Young Son, Tae-Young Na, Min-Ho Lee, Hyun-Jin Kang, Jinyoung
Park, Won-Jea Cho, Sang-Gun
Kim, Seung-Hoi Koo, Hyeung-geun
Park, and Mi-Ock Lee, Hepatology, (2012),
55 (5), 1379-1388.
87)
Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing
chlorophenyl and phenolic moiety, Pritam Thapa, Radha Karki, Minho Yun, Tara
Man Kadayat, Eunyoung Lee, Han Byeol Kwon, Youngwha Na, Won-Jea Cho, Nam Doo Kim, Byeong-Seon
Jeong, Youngjoo Kwon, Eung-Seok Lee, , Eur. J. Med Chem.,(2012),
52, 123-136 .
86) Dihydroxylated 2,4,6-triphenyl
pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity,
and structureeactivity relationship study, Radha Karki, Pritam Thapa, Han
Young Yoo, Tara Man Kadayat, Pil-Hoon Park, Youngwha Na, Eunyoung Lee, Kyung-Hwa
Jeon, Won-Jea Cho, Heesung
Choi, Youngjoo Kwonc, Eung-Seok Lee, Eur. J. Med Chem.,
(2012), 49, 219-228.
85) Synthesis of 12-oxobenzo[c]phenanthridinones
and 4-substituted 3-arylisoquinolinones via Vilsmeier-Haack reaction, Daulat Bikram Khadka, Su Hui Yang, Suk Hee Cho, Chao Zhao, Won-Jea Cho, Tetrahedron, (2012), 68, 250-261.
84) 2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h]quinoline
derivatives for topoisomerase I and II inhibitory activity, cytotoxicity,
and structure-activity relationship study, Pritam Thapa, Radha Karki, Han Young Yoo,
Pil-Hoon Park, Eunyoung Lee, Kyung-Hwa Jeon, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee,
Bioorganic Chemistry,
(2012), 40, 67-78..
83) Structural requirement of phenylthiourea
analogs for their inhibitory activity of melanogenesis and tyrosiase, Pillaiyar
Thanigaimalai, Ki-Cheul Lee, Vinay K. Sharma, Cheonik Joo, Won-Jea Cho,
Eunmiri Roh, Youngsoo Kim, Sang-Hun Jung, Bioorg. Med. Chem. Lett,
(2011), 21 (22), 6824-6828.
82) Synthetic approaches to natural antioxidant Benzastatin E, F and G
analogues, Thanh Nguyen Le, Su Hui Yang, Daulat Bikram Khadka, Suk Hee Cho, Chao Zhao, Won-Jea Cho, Bull. Korean Chem. Soc.,
(2011), 32 (12), 4309-4315.
81) Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines
via ring closing metathesis and evaluation of topoisomerase I inhibitory activity,
cytotoxicity and docking study, Hue Thi My Van, Daulat Bikram Khadka, Su Hui Yang, Thanh Nguyen Le, Suk Hee Cho, Chao Zhao, Ik-Soo
Lee, Youngjoo Kwon, Kyung-Tae Lee, Yong-Chul Kim, Won-Jea Cho, Bioorg. Med. Chem., (2011),
19 (18), 5311-5320.
80) Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase
I and II inhibitory activity, cytotoxicity, and structureeactivity relationship,
Uttam Thapa, Pritam Thapa, Radha Karki, Minho Yun, Jae Hun Choi, Yurngdong
Jahng, Eunyoung Lee, Kyung-Hwa Jeon, Younghwa Na, Eun-Mi Ha, Won-Jea Cho, Youngjoo Kwon, Eung-Seok
Lee, Eur. J. Med. Chem.
(2011), 46, 3201-3209.
79) Application of Ring-Closing Metathesis for the synthesis of Benzo[3,4]azepino[1,2-b]isoquinolin-9-ones,
Hue Thi My Hue, Daulat Bikram Khadka, Thanh Nguyen Le, Su Hui Yang, Won-Jea Cho, Chem. Pharm. Bull.,
(2011), 59 (9), 1169-1173.
78) Development of kNN QSAR Models for 3-Arylisoquinoline Antitumor Agents,
Alexander Tropsha, Alexander Golbraikh, Won-Jea Cho, Bull. Korean Chem. Soc.,
(2011), 32 (7), 2397-2404.
77) The 3-deoxy ananlogue of a-GalCer: Disclosing the role of the 4-hydroxy
group for CD1d-mediated NKT cell activation, Dong Jae Baek, Jeong-Hwan Seo,
Chaemin Lim, Jae Hyun Kim, Doo Hyun Chung, Won-Jea Cho, Chang-Yuil Kang,
and Sanghee Kim, ACS
MedChemLett., (2011), 2 (7), 544-548.
76) Design, synthesis of 4-amino-2-phenylquinazolines
as novel topoisomerase I inhibitors with molecular modeling, Thanh Nguyen
Le, Su Hui Yang, Daulat Bikram Khadka, Hue Thi My Van, Suk Hee Cho,
Youngjoo Kwon, Eung-Seok Lee, Kyung-Tae Lee, Won-Jea Cho, Bioorg. Med. Chem., (2011),
19, 4399-4404.
75) Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines
as novel topoisomerase I inhibitors, Daulat Bikram Khadka, Quynh Manh Le, Su Hui Yang, Hue Thi My Van, Thanh Nguyen
Le, Suk Hee Cho, Youngjoo Kwon, Kyung-Tae Lee, Eung-Seok Lee, Won-Jea Cho, Bioorg. Med. Chem., (2011),
19 (6), 1924-1929.
74) 3-Arylisoquinolines as novel topoisomerase I inhibitors, Daulat Bikram Khadka, Won-Jea Cho, Bioorg. Med. Chem., (2011),
19 (2), 724-734.
73) Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors,
Su Hui Yang, Daulat Bikram Khadka, Suk Hee
Cho, Hye-Kyung Ju, Kwang Youl Lee, Kyung-Tae Lee, Won-Jea Cho, Bioorg. Med. Chem., (2011),
19 (2), 968-977.
72) Effects of 3-phenyl-1-isoquinolinamine
on the metabolism of beta-amyloid precursor protein in neuroblastoma cells,
Jae-Yoon Leem and Won-Jea Cho,
Yakhak Hoeji,
(2010), 54 (6), 529-534.
71) CWJ-081, a novel 3-arylisoquinoline derivative, induces apoptosis in
human leukemia HL-60 cells partially involves reactive oxygen species through
c-Jun NH2-terminal kinase pathway So-Jung Won, Kyung-Sook Chung, Yo Sook Ki,
Jung-Hye Choi, Won-Jea Cho,
Kyung-Tae Lee, Bioorg. Med. Chem. Lett.,
(2010), 20 (22), 6447-6451.
70) Development of 3-aryl-1-isoquinolinamines as potent antitumor agents
based on CoMFA, Su Hui Yang, Hue Thi My Van,
Thanh Nguyen Le, Daulat Bikram Khadka, Suk Hee Cho, Kyung-Tae Lee, Eung-Seok
Lee, Young Bok Lee, Chang-Ho Ahn, Won-Jea Cho, Eur. J. Med. Chem.
(2010), 45 (11), 5493-5497.
69) Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines
as potent antitumor agents, Su Hui Yang, Hue Thi My Van, Thanh Nguyen Le,
Daulat Bikram Khadka, Suk Hee Cho, Kyung-Tae Lee, Hwa-Jin Chung, Sang Kook
Lee, Chang-Ho Ahn, Young Bok Lee, Won-Jea Cho, Bioorg. Med. Chem. Lett.,
(2010), 20 (17), 5277-5281.
68) Rational design and evaluation of a branched-chain-containg glycolipid
antigen that binds to CD1d, Dong Jae Baek, Yoon-Sook Lee, Chaemin Lim, Doohyun
Lee, Taeho Lee, Jae-Young Lee, Kyoo-A Lee, Won-Jea Cho, Chang-Yuil Kang,
Sanghee Kim, Chemistry
Asian J., (2010), 5 (7), 1560-1566.
67) Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity,
and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl
pyridines, Radha Karki, Pritam Thapa, Mi Jeong Kang, Tae Cheon Jeong, Jung
Min Nam, Hye-Lin Kim, Youngwha Na, Won-Jea Cho, Youngjoo Kwon, Eung-Seok
Lee, Bioorg. Med. Chem.,
(2010), 18, 3066-3077.
66) Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives
and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity,
and structure-activity relationship, Pritam Thapa, Radha Karki, Hoyoung Choi,
Jae Hun Choi, Minho Yun, Byeong-Seon Jeong, Mi-Ja Jung, Jung Min Nam, Younghwa
Na, Won-Jea Cho, Youngjoo
Kwon, and Eung-Seok Lee, Bioorg. Med. Chem.,
(2010), 18, 2245-2254..
65) Molecular mechanism of hydroquinone-mediated immunosuppressive effect:
Implication of Akt cystein 310 residue as a promising anti-inflammatory drug
target site, Ji Yeon Lee, Ae Ra Kim, Keum-Jin Yang, Jongsun Park, Byong Chul
Yoo, Sanghee Kim, Won-Jea Cho,
and Jae Youl Cho, J.
Biol. Chem., (2010), 285 (13), 9932-9948.
64) 2,6-Dithienyl-4-furyl pyridines: synthesis, topoisomerase I and II
inhibition, cytotoxicity, structure-activity relationship, and docking study,
Arjun Basnet, Pritam Thapa, Radha Karki, Hoyoung Choi, Jae Hun Choi, Minho
Yun, Byeong-Seon Jeong, Yurngdong Jahng, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, Chong-Soon
Lee and Eung-Seok Lee, Bioorg. Med. Chem. Lett.,
(2010), 20, 42-47.
63) Total synthesis of 8-oxypseudopalmatine
and 8-oxypseudoberberine via Ring Closing Metathesis, Hue Thi My Van, Su Hui
Yang, Daulat Bikram Khadka, Yong-Chul Kim, Won-Jea Cho, Tetrahedron, (2009), 65, 10142-10148.
62) Synthesis and structure-activity relationships of pyrazolodiazepine
derivatives as human P2X7 receptor antagonists, Ju-Yeon Lee, Yuan Yu, Won-Jea Cho, Hyojin Ko, Youg-Chul
Kim, Bioorg. Med. Chem.
Lett., (2009), 19, 6053-6058.
61) Molecular design, synthesis
and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as
topoisomerase I inhibitors, Suh-Hee Lee, Hue Thi My Van, Su-Hui Yang, Kyung-Tae
Lee, Youngjoo Kwon, Won-Jea Cho,
Bioorg. Med. Chem.
Lett., (2009), 19 (9), 2444-2447.
60) Structural modification of 3-arylisoquinolines to isoindolo[2,1-b]isoquinolinones
for the development of novel topoisomerase I inhibitors with molecular docking
study, Hue Thi My Van, Won-Jea Cho,
Bioorg. Med. Chem.
Lett., (2009), 19 (9), 2551-2554..
59) First total synthesis of
the phenolic 7,8-dihydro-8-oxoprotoberberine alkaloid, cerasonine, Thanh
Nguyen Le, Won-Jea Cho,
Chem. Pharm. Bull.,
(2008), 56 (7), 1026-1029.
58) Indeno[1,2-c]isoquinolines as enhancing agents on all-trans-retinoic
acid-mediated differentiation of human myeloid leukemia cells,
Seung Hyun Kim, Sang Mi Oh, Ju Han Song, Daeho Cho, Quynh Manh Le, Suh-Hee
Lee, Won-Jea Cho, Tae Sung
Kim, Bioorg. Med. Chem.,
(2008), 16 (3) 1125-1132.
57) Hydroquinone, a Major Component in Cigarette Smoke, Reduces IFN-gamma
Production in Antigen-Primed Lymphocytes, Jin Myung Choi, Young-Chang Cho,
Won-Jea Cho, Tae Sung Kim,
and Bok Yun Kang, Arch.
Pharm. Res., (2008), 31 (3), 337-341.
56) Application of Coupling Reaction between Lithiated Toluamide and Benzonitrile
for the Synthesis of Phenolic Benzo[c]phenanthridine Alkaloid, Oxyterihanine,
Thanh Nguyen Le, Hue Thi My Van, Suh-Hee Lee, Hyun Jin Choi, Kwang Youl Lee,
Bok Yun Kang, and Won-Jea Cho,
Arch. Pharm. Res.,(2008),
31 (1), 6-9.
55) Metformin inhibits hepatic gluconeogenesis through
AMP-activated protein kinase dependent regulation of the orphan nuclear receptor
SHP, Yong Deuk Kim1, Keun-Gyu Park, Yong-Soo Lee, Yun-Yong Park, Don-Kyu Kim,
Balachandar Nedumaran, Won Gu Jang, Won-Jea Cho, Joohun Ha, In-Kyu
Lee, Chul-Ho Lee, Hueng-Sik Choi, Diabetes, (2008), 57,
306-314.
54) Synthesis and
Evaluation of Hydroquinone Derivatives as Inhibitors of Isocitrate Lyase,
Hyeong-Cheol Yang, JiSu Yu, Ki-Bong Oh, Dong-Sun Shin, Won-Jea Cho, Jongheon Shin, and
Sanghee Kim, Arch. Pharm.
Res., (2007), 30 (8), 955-961.
53)
Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms
of 3-arylisoquinolines and docking study of a topoisomerase 1 inhibitor
into DNA-topoisomerase 1 Complex, Hue Thi My Van, Quynh Manh Le, Kwang Youl
Lee, Eung-Seok Lee, Youngjoo Kwon, Tae Sung Kim, Thanh Nguyen Le, Suh-Hee
Lee, Won-Jea Cho, Bioorg. & Med. Chem. Lett., (2007), 17, 5763-5767.
52) Design,
Docking and Synthesis of Novel Indeno[1,2-c]isoquinolines for the Development
of Antitumor Agents as Topoisomerase 1 Inhibitors, Won-Jea
Cho, Quynh Manh Le, Hue
thi My Van, Kwang Youl Lee, Bok Yun Kang, Eung-Seok Lee,Sang Kook Lee, Youngjoo
Kwon, Bioorg. & Med. Chem. Lett., (2007), 17 (13), 3531-3534.
51) Novel Synthesis of the
Natural Protoberberine Alkaloids: Oxypalmatine and Oxypseudopalmatine, Thanh
Nguyen Le, Won-Jea
Cho, Bull.
Korean. Chem. Soc., (2007),
28 (5), 763-766.
50) Synthesis and Evaluation
of 1,2,3-Triazole Containing Analogues of the Immunostimulant alhpa-GarCer,
Taeho Lee, Chang-Yuil Kang, Minjae Cho, Sung-Youl Ko, Hyun-Jun Youn, Dong
Jae Baek, Won-Jea
Cho, Sanghee Kim, J.
Med. Chem., (2007) 50
(3), 585-589.
49) A Concise Synthesis of 8-Oxoberbrine and Oxychelerythrine, Natural
Isoquinoline Alkaloids through Biomimetic Synthetic Way, Thanh Nguyen Le,
Won-Jea
Cho, Bull.
Korean. Chem. Soc., (2006),
27 (12), 2093-2096.
48) Total Synthesis of Oxyfagaronine,
Phenolic Benzo[c]phenanthridine and General Synthetic Way of 2,3,7,8- and
2,3,8,9-Tetrasubstituted Benzo[c]phenanthridine Alkaloids, Thanh Nguyen Le,
Won-Jea
Cho, Chem.
Pharm. Bull., (2006),
54(4), 476-480.
47) Synthesis of Oxychelerythrine Using Lithiated Toluamide-Benzonitrile
Cycloaddition, Thanh Nguyen Le, Won-Jea Cho, Chem. Pharm. Bull., (2005), 53 (1), 118-120.
46) Ketorolac Amide Prodrugs
for Transdermal Delivery: Stability and In vitro Rat Skin Permeation Studies,
Bo-Yeon Kim, Hea-Jeong Doh, Thanh Nguyen Le, Won-Jea Cho, Chul-Soon Yong, Han-Gon Choi, Jung
Sun Kim, Chi-Ho Lee and Dae-Duk Kim, Int. J. Pharmaceutics, (2005),293, 193-202.
45) Synthesis, Topoisomerase
Inhibition and Structure Activity Relationship Study of 2,4,6-Trisubstituted
Pyridine Derivatives, Long-Xuan Zhao, Yoon-Soo Moon, Arjun Basnet, Eun-Kyung
Kim, Yurndong Jahng, Jae Gyu Park, Tae Cheon Jeong, Won-Jea Cho, Sang-Un Choi, Chong Ock Lee, Sun-Young
Lee, Chong-Soon Lee and Eung-Seok Lee, Bioorg. & Med. Chem. Lett., (2004), 14, 1333-1337.
44) A Facile Synthesis of
Benzo[c]phenanthridine Alkaloids: Oxynitidine
and Oxysanguinarine Using Lithiated Toluamide-Benzonitrile Cycloaddition,
Than Nguyen Le, Seong Gyoung Gang, Won-Jea
Cho, Tetrahedron Lett., (2004) 45 (13), 2763-2766.
43) A Versatile Total Synthesis
of Benzo[c]phenanthridine and Protoberberine
Alkaloids Using Lithiated Toluamide-Benzonitrile Cycloaddition, Than Nguyen
Le, Seong Gyoung Gang, Won-Jea
Cho, J. Org.Chem., (2004) 69 (8), 2768-2772.
42) Discovery of Diarylacrylonitriles
as a Novel Series of Small Molecule Sortase A Inhibitors, Ki-Bong Oh, Soo-Whan
Kim, Jaekwang Lee, Won-Jea
Cho, Taeho Lee, and Sanghee
Kim, J. Med. Chem., (2004) 47 (10), 2418-2421.
41) Synthesis of New 3-Arylisoquinolinamines:
Effect on Topoisomerase I Inhibition and Cytotoxicity, Won-Jea Cho,
Sun Young Min, Thanh Nguyen Le, Tae Sung Kim, Bioorg. & Med. Chem.
Lett., (2003), 13, 4451-4454 .
40) Comparative Molecular
Field Analysis Study for Stilbene Derivatives Active against A549 Lung Carcinoma,
Sanghee Kim, Sun Young Min, Sang Kook Lee, Won-Jea Cho, Chem.
Pharm. Bull.(2003), 51 (5), 516-521.
39) Synthesis and Evaluation
of Ketorolac Ester Prodrugs for Transdermal Delivery, Hea-Jeong Doh, Won-Jea
Cho, Chul-Soon Yong, Han-Gon Choi, Jung Sun Kim, Chi-Ho Lee, Dae-Duk Kim,
J. Pharm. Sci. (2003), 92 (5), 1008-1017.
38) Synthesis and Biological
Evaluation as a Potential Allylamine Type Antimycotics, Byung-Ho Chung, Won-Jea Cho, Seung Hoon Cheon,
Soon-Young Chung and Jin-Cheol Yoo, Yakhak Hoeji, (2003),
47 (5), 293-299.
37) In Intro Rat Skin Permeation
of Various NSAIDs, Min-Jung Kim, Hea-Jeong Doh, Won-Jea Cho, Chul-Soon
Yong, Han-Gon Choi, Chi-Ho Lee and Dae Duk Kim, J. Kor. Pharm. Sci.,
(2002), 32 (4), 313-319.
36) Hypothetical Drug Binding
Receptor Site Analysis Using CoMFA Method for 3-Arylisoquinolines Active against
SK-OV-3 Tumor Cell line, Eui-Ki Kim, Sun Young Min, Byung-Ho Chung, Seung
Hoon Cheon, Bo-Gil Choi, and Won-Jea Cho, Yakkak Hoeji, (2002),
46 (4), 219-225.
35) Two-week oral toxicity
study of 1-(4-methylpiperazinyl)-3-phenylisoquinoline(CWJ-a-5) in Sprague-Dawley(SD)
rats. Boo-Hyon Kang, Won-Jea Cho, Dae-Duk Kim, Yong-Bum Kim, Sin-Woo
Cha, Soon-Jae Chang. J. Toxicol. Pub. Health, (2002), 18,
47-57.
34) Physicochemical Properties
of CWJ-a-5, a New Antitumor 3-Arylisoquinoline Derivative, K. E. Kim, W.-J.
Cho, T. S. Kim, B. H. Kang, S. J. Chang, C. H. Lee, and D. D. Kim, Drug
Devel. Ind. Pharm. (2002), 28 (7), 889-895.
33) Molecular Modeling of
3-Arylisoquinoline Antitumor Agents Active against A-549. A Comparative Molecular
Field Analysis Study, Won-Jea Cho, Eui-Ki Kim, Il Yeong Park, Eun Young
Jeong, Tae Sung Kim, Thanh Nguyen Le, Dae-Duk Kim, and Eung-Seok Lee, Bioorg.
& Med. Chem., (2002), 10 (9), 2953-2961.
32) Synthesis, Topoisomerase
I Inhibition and Antitumor Cytotoxicity of 2,2':6',2"-, 1,2':6',3"- and 2,2':6',4"-
Terpyridine Derivatives, Long-Xuan Zhao, Tae Sung Kim, Soo-Hyun Ahn, Tae-Hyung
Kim, Eun-kyung Kim, Won-Jea Cho, Heesung Choi, Chong-Soon Lee, Jung-Ae
Kim, Tae Cheon Jeong, Ching-jer Chang and Eung-Seok Lee, Bioorg. &
Med. Chem. Lett., (2001), 11, 2659-2662.
31) Pharmacokinetics of a
new antitumor 3-arylisoquinoline derivative CWJ-a-5. Kim, Ki Eun; Cho, Won Jea; Chang, Soon Jae; Yong, Chul Soon;
Lee, Chi Ho; Kim, Dae Duk. Int. J. Pharmaceutics,
(2001), 217, 101-110.
30) Rat Skin Permeation of
Diclofenac and its Prodrugs. Hea-Jeong Doh, Won-Jea Cho, Chul-Soon
Yong, Chi-Ho Lee, Dae-Duk Kim, J. Kor. Pharm. Sci., (2001):
31 (2): 95-100.
29) Effects of the Acute and
Subacute Adiministration of 1-(N-methyl)piperazinyl -3- phenyl- isoquinoline
on Rat Kidney. Park, Sun Hee; Noh, Eun Young; Kim, Han Soo; Cho, Won Jea; Lim, Dong Koo. J. Toxicol.
Pub. Health, (2000): 16 (1): 47-52
28) A convenient synthesis
of 5-methylbenzo[c]phenanthridin-6(5H)-one. Cho, Won-Jea; Kim, In
Jong; Park, Sun-Ja. Bull. Korean Chem. Soc. (2000), 21(10),
1035-1038.
27) Convenient synthesis of
2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids.
Hanaoka, Miyoji; Hirasawa, Taeko; Cho, Won Jea; Yasuda, Shingo. Chem.
Pharm. Bull. (2000), 48(3), 399-404.
26) A novel synthesis of benzo[c]phenanthridine
skeleton and biological evaluation of isoquinoline derivatives. Cho, Won-Jea;
Park, Myun-Ji; Imanishi, Takeshi; Chung, Byung-Ho. Chem. Pharm. Bull.
(1999), 47(6), 900-902.
25) Synthesis of sesquiterpene
derivatives as potential antitumor agents; elemane derivatives. Choi, Bo Gil;Kwak,
Eun Yee; Chung, Byung Ho; Cho, Won Jea; Cheon, Seung Hoon. Arch.
Pharmacal Res. (1999), 22(6), 575-578.
24) Synthesis of novel 2-(3-substituted)propionic
acid derivatives. Chung, Byung-Ho; Eam, Chun-Sung; Cho, Won-Jea; Cheon,
Seung-Hoon. Yakhak Hoeji (1999), 43(3), 320-327
23) Studies on the synthesis
and in vitro antitumor activity of the isoquinolone derivatives. Cheon, Seung
Hoon; Lee, Joon Yeol; Chung, Byung-Ho; Choi, Bo-Gil; Cho, Won-Jea;
Kim, Tae Sung. Arch. Pharmacal Res. (1999), 22(2), 179-183.
22) Synthesis and comparative
molecular field analysis (CoMFA) of antitumor 3-arylisoquinoline derivatives.
Cho, Won-Jea; Kim, Eui-Ki; Park, Myun-Ji; Choi, Sang-Un; Lee, Chong-Ock;
Cheon, Seung Hoon; Choi, Bo-Gil; Chung, Byung-Ho. Bioorg. Med. Chem.
(1998), 6(12), 2449-2458.
21) Prediction of the binding
mode of imidacloprid and related compounds to house-fly head acetylcholine
receptors using three-dimensional QSAR analysis. Okazawa, Atsushi; Akamatsu,
Miki; Ohoka, Akira; Nishiwaki, Hisashi; Cho, Won-Jea; Nakagawa, Yoshiaki;
Nishimura, Keiichiro; Ueno, Tamio. Pestic. Sci. (1998), 54(2),
134-144.
20) Synthesis and biological
evaluation of 3-arylisoquinolines as antitumor agents. Cho, Won-Jea;
Park, Myun-Ji; Chung, Byung-Ho; Lee, Chong-Ok. Bioorg. Med. Chem. Lett.
(1998), 8(1), 41-46.
19) Synthesis and structure-activity
relationship studies of substituted isoquinoline analogs as antitumor agent.
Cheon, Seung Hoon; Park, Joon Suck; Chung, Byung-Ho; Choi, Bo-Gil; Cho, Won-Jea; Choi, Sang-Un; Lee, Chong-Ock. Arch. Pharmacal Res. (1998), 21(2), 193-197
18) Synthesis of antineoplaston
A10 analogs as potential antitumor agents. Choi, Bo-Gil; Kim, Ok-Young; Chung,
Byung-Ho; Cho, Won-Jea; Cheon, Seung-Hoon; Choi, Sang-Un; Lee, Chong-Ock.
Arch. Pharmacal Res. (1998), 21(2), 157-163.
17) Synthesis and antitumor
activity of 3-arylisoquinoline derivatives. Cho, Won-Jea; Yoo, Su-Jeong;
Park, Myun-Ji; Chung, Byung-Ho; Lee, Chong-Ock. Arch. Pharmacal Res.
(1997), 20(3), 264-268
16) Synthesis and antitumor
activity of antineoplaston A10 analogs as potential antineoplastic agents.
Choi, Bo-Gil; Seo, Hee-Kyoung; Kim, Ok-Young; Chung, Bung-Ho; Oh, In-Jun;
Cho, Won-Jea; Cheon, Seung-Hoon; Park, Min-Soo; Choi, Sang-Un; Lee,
Chong-Ock. Yakhak Hoechi (1997), 41(3), 283-293.
15) Synthesis and structure-activity
relationship studies of 2,3-dihydroimidazo[2,1- a]isoquinoline analogs as
antitumor agents. Cheon, Seung Hoon; Park, Joon Suck; Jeong, Seon Hee; Chung,
Byung-Ho; Choi, Bo-Gil; Cho, Won-Jea; Kang, Boo-Hyon; Lee, Chong-Ock.
Arch. Pharmacal Res. (1997), 20(2), 138-143.
14) Synthesis and biological
evaluation of allylamine antimycotics. Chung, Byung-Ho; Cho, Won-Jea;
Cheon, Seung-Hoon; Park, Myun-Ji; Yoo, Jin-Cheol; Chun, Moon-Woo. Yakhak
Hoechi (1997), 41(2), 187-194.
13) Synthesis of benzo[c]phenanthridine
derivatives and their in vitro antitumor activities. Cho, Won-Jea;
Yoo, Su-Jeong; Chung, Byung-Ho; Choi, Bo-Gil; Cheon, Seung Hoon; Whang, Soon-Ho;
Kim, Sin-Kyu; Kang, Boo-Hyon; Lee, Chong-Ock. Arch. Pharmacal Res.
(1996), 19(4), 321-325
12) A first synthesis of isofagaridine:
topoisomerase I inhibitor. Cho, Won-Jea; Hanaoka, Miyoji. Arch.
Pharmacal Res. (1996), 19(3), 240-242.
11) Design and stereoselective
synthesis of conformationally constrained analogs of zimeldine. Cho, Won-Jea; Grunewald, Gary L. Arch. Pharmacal Res. (1996), 19(2), 168-170
10) Optically active tricarbonyl(h6-o-trimethylsilylbenzaldehyde)chromium(0)
complexes in organic synthesis: a highly diastereoselective 1,3-dipolar cycloaddition
with electron-rich olefins. Mukai, Chisato; Kim, In Jong; Cho, Won Jea; Kido, Masaru; Hanaoka, Miyoji. J. Chem. Soc., Perkin Trans. 1 (1993), (20), 2495-503
9) A first total synthesis
of ( ±)-ambinine. Hanaoka, Miyoji; Cho, Won Jea; Sugiura, Yoko; Mukai,
Chisato. Chem. Pharm. Bull. (1991), 39(1), 242-3
8) Asymmetric aldol reaction:
a highly erythro-selective aldol reaction between tricarbonyl(o-trimethylsilylbenzaldehyde)chromium(0)
complexes and cyclic silyl enol ethers. Mukai, Chisato; Cho, Won Jea;
Kim, In Jong; Kido, Masaru; Hanaoka, Miyoji. Tetrahedron (1991),
47(18-19), 3007-36.
7) Chemical transformation
of protoberberines. XVII. Biomimetic introduction of an oxy functionality
at the C-10 position in the benzo[c]phenanthridine skeleton: synthesis of
2,3,7,8,10-pentaoxygenated benzo[c]phenanthridine alkaloids, chelilutine
and sanguilutine. Hanaoka, Miyoji; Cho, Won Jea; Yoshida, Shuji; Mukai,
Chisato. Chem. Pharm. Bull. (1991), 39(5), 1163-6
6) Tricarbonyl(benzaldehyde)chromium(0)
complexes in organic synthesis: a highly stereoselective 1,3-dipolar cycloaddition
of chromium(0)-complexed nitrones. Mukai, Chisato; Cho, Won Jea; Kim,
In Jong; Hanaoka, Miyoji. Tetrahedron Lett. (1990), 31(47),
6893-6.
5) Chemical transformation
of protoberberines. XVI. Regioselective introduction of an oxy functionality
at the C12-position of the benzo[c]phenanthridine skeleton: a convenient
synthesis of macarpine from oxychelirubine. Hanaoka, Miyoji; Cho, Won Jea;
Yoshida, Shuji; Fueki, Tsukasa; Mukai, Chisato. Chem. Pharm. Bull.
(1990), 38(12), 3335-40.
4) A highly erythro selective
aldol reaction between chromium-complexed benzaldehyde derivatives and cyclic
silyl enol ethers. Mukai, Chisato; Cho, Won Jea; Hanaoka, Miyoji.
Tetrahedron Lett. (1989), 30(52), 7435-8.
3) A new and convenient synthesis
of macarpine and dihydromacarpine from oxychelirubine. Hanaoka, Miyoji; Cho,
Won Jea; Yoshida, Shuji; Fueki, Tsukasa; Mukai, Chisato. Heterocycles
(1989), 29(5), 857-60.
2) A novel and biomimetic
synthesis of chelilutine and sanguilutine. Hanaoka, Miyoji; Cho, Won Jea;
Yoshida, Shuji; Mukai, Chisato. Chem. Pharm. Bull. (1989), 37(3),
857-8
1) Chemical transformation
of protoberberines. XI. A novel synthesis of 2,3,10,11-tetraoxygenated protoberberine
alkaloids from corresponding 2,3,9,10-tetraoxygenated protoberberine alkaloids.
Hanaoka, Miyoji; Cho, Won
Jea; Marutani, Mari; Mukai,
Chisato. Chem. Pharm. Bull.
(1987), 35(1), 195-9.